What is Hydroxyphenyl Propamidobenzoic Acid Used For

2024-05-27 12:46:07

What is Hydroxyphenyl Propamidobenzoic Acid Used For

Hydroxyphenyl propamidobenzoic acid, commonly referred to by its trade name SymCalmin, is a synthetic compound known for its soothing and anti-irritant properties. This ingredient is particularly noted for its ability to mimic the natural soothing effects of avenanthramides, active compounds found in oats.


Uses and Benefits

Skincare Items:

Salves and Creams: SymCalmin is normally integrated into saturating moisturizers and creams to mitigate aggravated skin and diminish redness, making these items appropriate for everyday use, particularly for delicate skin types.

After-sun Items: It is utilized in after-sun salves and gels to quiet skin after sun openness, assisting with lightening burn from the sun related bothering and distress.

Against maturing Items: Tracked down in enemy of maturing creams and serums to decrease skin uneasiness and irritation that can be related with strong enemy of maturing fixings.

Corrective Items:

Establishments and Preliminaries: SymCalmin is incorporated to limit skin aggravation, guaranteeing that cosmetics items are delicate enough for touchy skin and lessening the probability of redness and bothering.

Cosmetics Removers: Guarantees that the evacuation cycle is delicate on the skin, lessening the potential for bothering and making cosmetics expulsion a mitigating experience.

Individual Consideration Items:

Shampoos and Conditioners: Used to mitigate the scalp and decrease disturbance, making these items helpful for people with delicate scalps or conditions like dandruff.

Body Washes and Cleansers: Integrated to help alleviate and shield the skin from unforgiving purifying specialists, making these items more reasonable for those with delicate or effortlessly bothered skin.


Alleviating Impact:

SymCalmin imitates the normal quieting impacts of avenanthramides found in oats, which are notable for their capacity to decrease aggravation and uneasiness in the skin. This makes SymCalmin a compelling mitigating specialist.

Hostile to aggravation Properties:

Assists with diminishing redness, tingling, and general distress related with disturbed skin. This makes it especially important in details for delicate skin.


The compound has calming properties, which help in lessening aggravation. This is valuable for overseeing conditions like dermatitis, psoriasis, and other provocative skin problems.

Improved Skin Obstruction:

SymCalmin upholds the skin's obstruction capability, assisting with safeguarding against natural stressors and lessening the gamble of additional disturbance. This can further develop by and large skin wellbeing and versatility.

Flexible Application:

Can be utilized in various plans, from pass on items like lotions to flush off items like shampoos and body washes. Its flexibility makes it a profoundly flexible fixing in private consideration items.

Applications in Skincare Products

Moisturizers and Creams:

Daily Moisturizers: SymCalmin is included in formulations to provide daily hydration while soothing and calming the skin, making them suitable for sensitive skin types.

Night Creams: Used in night creams to help reduce irritation and promote skin repair overnight, ensuring a calm and rejuvenated complexion by morning.


Anti-aging Serums: Incorporated into serums to reduce the irritation that can be caused by potent active ingredients like retinoids and Hydroxyphenyl propamidobenzoic acid, while also addressing inflammation associated with aging.

Hydrating Serums: Used in serums designed to boost hydration levels while providing a calming effect, ideal for dehydrated and sensitive skin.

After-sun Care:

After-sun Lotions and Gels: Applied to soothe and calm the skin after sun exposure, reducing redness and discomfort associated with sunburn.

Aloe Vera Gels: Enhanced with SymCalmin to amplify the soothing effects of aloe vera for post-sun skincare.

Cleansers and Face Washes:

Gentle Cleansers: Used in formulations to ensure a gentle cleansing experience that does not strip the skin of its natural oils, reducing the risk of irritation and dryness.

Exfoliating Cleansers: Added to exfoliating cleansers to mitigate the potential irritation caused by exfoliating agents, making them gentler on the skin.

Face Masks:

Sheet Masks: Incorporated into sheet masks designed to provide intensive soothing and hydration, making them perfect for calming irritated or stressed skin.

Clay Masks: Used in clay masks to balance the drying effect of clay with soothing properties, making these masks suitable for sensitive and oily skin types.


Mechanism of Action

Soothing Effect: SymCalmin acts as a mimetic of avenanthramides, which are known for their ability to soothe irritated skin. Avenanthramides exert their calming effect by modulating various pathways involved in skin inflammation and irritation.

Anti-irritant Properties: SymCalmin helps to reduce skin redness, itching, and general discomfort associated with irritation. It achieves this by targeting inflammatory mediators and pathways involved in the skin's response to irritation and external stressors.

Anti-inflammatory Activity: SymCalmin exhibits anti-inflammatory properties, which are crucial for alleviating skin inflammation and preventing the exacerbation of inflammatory skin conditions. It may inhibit the production or activity of pro-inflammatory cytokines, enzymes, and other mediators involved in the inflammatory response.

Barrier Function Enhancement: SymCalmin supports the skin's barrier function, which is essential for maintaining skin health and preventing moisture loss. By strengthening the skin barrier, SymCalmin helps to protect the skin from external aggressors and reduce the risk of further irritation.

Modulation of Sensory Responses: SymCalmin may also modulate sensory responses in the skin, reducing the perception of discomfort and improving overall skin comfort. This can contribute to a subjective feeling of relief and well-being for individuals with sensitive or irritated skin.

Cellular Repair and Renewal: SymCalmin may promote cellular repair and renewal processes in the skin, helping to restore damaged tissue and maintain skin integrity. By supporting skin regeneration, SymCalmin contributes to the overall health and resilience of the skin barrier.

Safety and Efficacy


Non-Irritating: SymCalmin has been shown to be non-irritating and well-tolerated by the skin in various clinical studies. It is suitable for use in formulations designed for sensitive and reactive skin types.

Non-Sensitizing: SymCalmin is generally non-sensitizing, meaning it is unlikely to cause allergic reactions or sensitization in most individuals. However, as with any cosmetic ingredient, individual sensitivities can vary, and patch testing is recommended, especially for those with known sensitivities.

Dermatologist Tested: Many skincare products containing SymCalmin undergo dermatologist testing to ensure their safety for use on human skin. These tests typically include patch testing and repeated application studies to assess skin compatibility and potential adverse effects.

Compliance with Regulatory Standards: SymCalmin and products containing it comply with regulatory standards set by authorities such as the FDA (Food and Drug Administration) in the United States and the European Union's Cosmetic Regulation, ensuring their safety for consumer use.


Soothing Properties: SymCalmin has demonstrated efficacy in soothing and calming irritated skin. It helps reduce redness, itching, and discomfort associated with various skin conditions, including sunburn, eczema, and dermatitis.

Anti-inflammatory Activity: SymCalmin exhibits anti-inflammatory properties, which contribute to its efficacy in reducing skin inflammation and irritation. It helps modulate inflammatory pathways and mediators involved in the skin's response to external stressors.

Barrier Function Enhancement: SymCalmin supports the skin's natural barrier function, helping to strengthen and protect the skin against environmental aggressors. By enhancing the skin barrier, it improves moisture retention and reduces the risk of further irritation.

Clinical Studies: SymCalmin has been the subject of several clinical studies evaluating its efficacy in skincare formulations. These studies typically assess parameters such as skin hydration, redness reduction, and subjective improvements in skin comfort and appearance.

Consumer Satisfaction: Skincare products containing SymCalmin often receive positive feedback from consumers, with many reporting improvements in skin texture, hydration, and overall comfort after regular use.


Hydroxyphenyl propamidobenzoic acid is a valuable ingredient in the skincare industry, particularly for products targeting sensitive and irritated skin. Its ability to reduce redness, itchiness, and irritation, combined with its texture-enhancing properties, makes it a sought-after component in many high-quality skincare formulations. Whether you are dealing with dermatitis, eczema, or simply looking for a product to soothe and protect your skin, hydroxyphenyl propamidobenzoic acid offers significant benefits backed by scientific research.If you have any questions or would like to learn more about our products, please feel free to contact us at admin@chenlangbio.com.


  1. Paula's Choice Ingredient Dictionary
  2. Procoal Skin School
  3. INCI Decoder