Unveiling the Wonders of Phloretin Powder Extract from Apple Peel

2024-06-12 18:35:15

XI AN CHEN LANG BIO TECH CO., LTD supply high quality plant extract powder, cosmetics raw powder, pharmaceutical intermediates powder and so on. We mainly supply phloretin powder 98%. As a cosmetic raw material, phloretin has received widespread attention from researchers in thƒe beauty industry. In this article, we'll explore the physical and chemical properties, the production process of apple extract, its incredible benefits, the results of in vitro research, and the diverse applications of this remarkable substance.


Physical and Chemical Properties:

Phloretin 98% is a high-purity extract with unique properties:

Appearance: This compound presents as a fine, white to pale yellow powder.

Solubility: Phloretin has limited solubility in water but demonstrates better solubility in organic solvents, such as ethanol, acetone, and dimethyl sulfoxide (DMSO).

Molecular Structure: Its chemical formula is C15H14O5, and its molecular weight is 274.27 g/mol.

Stability: It is sensitive to light and heat, which is why proper storage is crucial to maintain its integrity.

The extraction of Phloretin from plant sources is a meticulous process that involves several steps:

Source Selection: The compound is primarily derived from the skin of apples and the bark of certain fruit trees. High-quality sources are crucial for a potent final product.

Extraction: The chosen plant material is crushed, ground, or macerated to release the active compounds. The extract is then subjected to various solvents to isolate phloretin.

Purification: The extract undergoes multiple purification steps, including filtration, distillation, and crystallization, to achieve a 98% purity level.

Quality Control: Rigorous quality control measures are employed to ensure the final product meets the desired standards. We always use HPLC to test the purity of our products and send sample to “Third Party Test” to test the purity, microorganisms and heavy metals, must control these data Data within standard range.

Phloretin Benefits:

1. Antioxidant and Anti-aging Properties

Phloretin's high antioxidant potency has been recognized since the 1960s. Its hydroxyl groups can chelate with metal ions, endowing it with remarkable antioxidant capabilities. This makes Phloretin a potent combatant against free radicals, preventing oxidative damage to the skin. In concentrations ranging from 10-30PPm, it effectively neutralizes free radicals that can cause skin aging and contribute to degenerative diseases. When topically applied, it restricts sugar components from entering epidermal cells, curbing excessive sebum secretion and aiding in the treatment of conditions like acne. Additionally, Phloretin has been shown to inhibit melanocyte activity, making it an effective skin-lightening agent. Its impact on tyrosinase enzymes makes it a safe and efficient depigmenting agent. Phloretin also boasts excellent moisturizing properties, with the ability to absorb four to five times its weight in water. It serves as a safe and effective transdermal permeation enhancer, aiding the absorption and efficacy of other functional factors in formulations. Furthermore, its inhibition of LOX (Lipoxygenase) makes it a promising anti-hair loss agent.

2. Anti-Inflammatory and Immunomodulatory Effects

Research indicates that inflammation is associated with Nitric Oxide (NO) production, which is catalyzed by NO synthase. In pathological conditions, inducible NO synthase can lead to excessive NO generation. Phloretin significantly reduces NO release by macrophages stimulated by lipopolysaccharides and interferon-gamma, demonstrating its potential anti-inflammatory effects. Additionally, under the influence of Phloretin, macrophage phagocytosis decreases significantly. This points to Phloretin's immunomodulatory potential.

In terms of immunomodulation, Phloretin is a known competitive inhibitor of sodium-dependent D-glucose cotransporters. By increasing the fluidity of the cell's lipid bilayer, it broadens the range and activity of drugs transported across the skin membrane.

3. Antitumor and Anticancer Activity

Phloretin's relevance extends to the realm of cancer research, particularly in the modulation of γδT cells. These specialized T cells reside in mucosal and epithelial tissues throughout the digestive and respiratory systems. They exhibit potent antitumor effects, including the ability to recognize antigens without requiring MHC molecule presentation, direct recognition of protein and peptide antigens, non-peptide antigens, and immunomodulatory functions through cell contact and cytokine secretion.

Phloretin's ability to impact these cells underscores its potential in the development of novel antitumor and anticancer therapies.

In Vitro Research Findings:

Phloretin's potential is substantiated by compelling in vitro research results:

A study published in the Journal of Investigative Dermatology found that phloretin reduced UV-induced skin damage, preventing the formation of age spots and wrinkles.

In a study published in the Journal of Agricultural and Food Chemistry, Phloretin demonstrated its ability to protect against oxidative stress, providing a shield against environmental aggressors.

Research in the Journal of Cosmetic Dermatology suggests that phloretin powder can improve the skin's elasticity and overall texture.

Phloretin Applications:

Phloretin can be used in facial masks, skin care creams, lotions and essences. Phloretin can be used in facial masks, skin care creams, lotions and essences. Phloretin can inhibit the excessive secretion of sebaceous glands and is used to treat excessive secretion of acne;it can inhibit the activity of melanocytes and has an effect on various skin stains. Compared with similar natural ingredients arbutin and kojic acid, the inhibitory effect of phloretin on tyrosinase at the same concentration is better than them, and when it is compounded with arbutin and/or kojic acid, it can greatly inhibit tyrosinase. Improve the product's inhibition rate of tyrosinase to 100%.

Phloretin has a very strong moisturizing effect and can absorb 4 to 5 times its own weight in water. It can promote the absorption and utilization of other functional factors in the formula, so that they can exert better effects.

It has a strong antioxidant function and can scavenge free radicals in the skin. The antioxidant concentration of oil is between (10~30)×10-6. It can prevent sugar components from entering epidermal cells, thereby inhibiting excessive secretion of cutaneous glands and treating acne with strong secretion; it can inhibit the activity of melanocytes and have a lightening effect on various skin spots. Phloretin can be used in facial masks, skin care creams, lotions and essences.


The remarkable 98% phloretin, extracted from plant sources, is a powerhouse ingredient in the world of skincare and wellness. With its exceptional antioxidant properties, skin-brightening abilities, and collagen-boosting potential, it has gained the admiration of beauty enthusiasts and researchers alike.

Supported by in vitro research, phloretin offers a range of benefits, and its versatility makes it suitable for various applications. Whether you're seeking a skincare savior or a new addition to your cosmetics collection, phloretin is a natural choice that holds the promise of radiant, youthful skin. Explore the wonders of phloretin powder, and let its natural charm elevate your beauty and wellness routine.

Please send inquiry to Email: admin@chenlangbio.com if you want to buy phloretin.