Fisetin Powder Manufacturer

We are fisetin powder manufacturer and supplier. Pure fisetin raw powder is senolytic activator. Many people like strawberries, because it has good effect on anti-aging, these all due to rich fisetin in strawberries. Fisetin is a natural flavonoid compound, which was first isolated and extracted from sumac tree in 1833. It has anti-oxidation, anti-inflammatory, anti-tumor, anti-aging and other effects.

Strong Antioxidant and Inflammation:

In 1966, an article published in "Nature" stated that fisetin was one of the flavonoids with the strongest antibacterial effect known at that time, and only 50 μg/ml was needed to effectively inhibit the growth of bacteria such as Staphylococcus aureus, which has caused scientists to pay attention to the pharmacological effects of fisetin. In follow-up research on fisetin, scientists discovered that it has antioxidant and anti-inflammatory effects.

As a flavonoid, fisetin is born with antioxidant properties. It not only has direct antioxidant activity, but also increases the level of the main antioxidant glutathione in cells. Even in the case of oxidative stress, fisetin can maintain mitochondrial function well, and even very fragile neuron cells can be well protected.

In addition to its own antioxidant, its anti-inflammatory effect should not be underestimated. Fisetin inhibits the NF-κB pro-inflammatory signaling pathway by activating β-catenin protein and silencing the expression of TLR4, thereby down-regulating the release of inflammatory cytokines and achieving anti-inflammatory effects.

It has strong anti-cancer effect:

Fisetin powder manufacturer Fisetin exerts inhibitory effects at various stages of tumor development.

Anti-aging Effect:

It is not only cancer that affects human health and longevity, but also aging. Fisetin is not only satisfied with the status quo of suppressing tumors, but also wants to make a contribution in delaying aging.

In 2007, Sinclair and others discovered that fisetin can activate SIRT1 longevity protein, and fisetin emerged in the anti-aging field. In 2007, Sinclair and others discovered that fisetin can activate SIRT1 longevity protein [10], and fisetin emerged in the anti-aging field. After the senolytic concept proposed by Dr. James Kirkland in 2015, fisetin has become a popular Senolytic substance and attracting more attention due to its powerful ability to clear senescent cells.

As a mimetic of caloric restriction, fisetin induces autophagy by up-regulating the expression of SIRT1 in the Sirtuins family, thereby inhibiting mTOR. Unlike other caloric restriction mimics such as metformin, fisetin is tissue-specific and has a better effect on promoting autophagy in brain cells.

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