What Is Fladrafinil (CRL-40,941)? Uses, Properties, and Research Overview

Introduction: Why Fladrafinil Matters in Nootropic Raw Material Sourcing

 

In the global nootropics and cognitive research market, fladrafinil nootropic has become an increasingly discussed compound among formulation developers and procurement professionals. Unlike consumer-facing ingredients, Fladrafinil is primarily evaluated and sourced as a nootropic raw material and pharmaceutical intermediate, where purity, batch consistency, and documentation integrity directly affect downstream research and formulation outcomes.

 

At CHEN LANG BIO TECH, we work with international buyers who source fladrafinil powder for research, product development, and long-term supply planning. From our experience, buyers searching for reliable fladrafinil suppliers are not simply looking for availability—they are looking for traceable quality, stable production, and a manufacturer who understands regulatory and technical expectations.

 

This article provides a research- and procurement-focused overview of fladrafinil, covering its chemical identity, functional positioning, comparison with related compounds, and key sourcing considerations relevant to overseas buyers.

 

 

Fladrafinil at a Glance: Chemical Identity and Core Specifications

 

For procurement teams and R&D managers, confirming the chemical identity of fladrafinil is the first and most critical step in supplier evaluation. The table below summarizes the most commonly requested technical data.

 

Parameter	Description
Chemical Name	Fladrafinil
Synonyms	CRL-40,941, Fluorafinil
CAS Number	fladrafinil CAS 90212-80-9
Molecular Formula	C15H13F2NO3S
Molecular Weight	325.3 g/mol
Appearance	White to off-white crystalline powder
Typical Purity	≥998% fladrafinil powder
Solubility	Soluble in DMSO, slightly soluble in water
Shelf Life	24 months (sealed, proper storage)
Package	1Kg/Aluminum foilbag, 25Kg/Paper drum

 

For professional buyers, this data is typically cross-checked against the Certificate of Analysis (COA) to ensure consistency between specification sheets and batch-level results.

 

How Fladrafinil Is Classified: Nootropic Compound vs. Pharmaceutical Intermediate

 

In commercial and research contexts, Fladrafinil nootropic is not positioned as a finished or consumer-ready ingredient. Instead, it is widely classified as a pharmaceutical intermediate used in early-stage research, formulation development, and ingredient evaluation.

 

Typical use scenarios include:

 

♦Nootropic formulation research;

 

♦Cognitive performance and wakefulness studies;

 

♦Ingredient comparison and screening programs;

 

♦Intermediate sourcing for controlled development pipelines.

 

In practical sourcing scenarios, companies looking to develop or evaluate bulk fladrafinil powder usually begin by reviewing how the material is produced and controlled, rather than how it is promoted. Procurement teams typically request batch-level data, analytical methods, and production background early in the evaluation process, especially when the material is intended for repeated research use or long-term formulation work.

 

Fladrafinil vs. Adrafinil vs. Modafinil: Practical Differences for Buyers

 

Fladrafinil is frequently compared with adrafinil and modafinil, particularly during early-stage research evaluation. While these compounds are structurally related, their procurement and sourcing considerations differ significantly.

 

Compound	Relationship	Typical Sourcing Context
Adrafinil	Parent compound	Precursor and early wakefulness research
Modafinil	Active metabolite	Clinical and pharmaceutical research
Fladrafinil	Fluorinated analog	Extended-duration nootropic research

 

In practice, formulation teams often document fladrafinil vs adrafinil and fladrafinil vs modafinil differences directly in internal sourcing notes, especially when multiple compounds are evaluated side by side.

 

Functional Properties and Mechanism of Action of Fladrafinil

 

In research and formulation literature, fladrafinil nootropic is primarily discussed in relation to its effects on wakefulness regulation and cognitive performance under sustained workload conditions. Rather than acting as a classical stimulant, Fladrafinil is structurally related to adrafinil and modafinil and is generally evaluated for its influence on central nervous system signaling pathways associated with alertness and fatigue resistance.

 

Mechanistically, studies suggest that Fladrafinil is involved in the modulation of neurotransmitter systems linked to wakefulness, particularly dopaminergic and adrenergic pathways. By influencing these systems, fladrafinil powder is often associated with improved maintenance of alertness and task engagement during prolonged cognitive activity, without the rapid onset–offset profile commonly observed with traditional stimulants.

 

From a functional perspective, research discussions and comparative formulation studies frequently reference the following characteristics:

 

♦Support for sustained wakefulness during extended cognitive or analytical tasks;

 

♦Reduced perception of mental fatigue in comparison models;

 

♦A longer functional duration when evaluated alongside adrafinil, particularly in time-on-task studies;

 

♦More stable activity profiles compared with short-acting wakefulness compounds.

 

Because of these properties, fladrafinil nootropic raw material is commonly included in early-stage formulation screening, especially when developers are assessing compounds intended for prolonged cognitive performance rather than acute stimulation.

 

It is important to note that these functional characteristics are described strictly within research, formulation, and ingredient evaluation contexts. Accordingly, bulk Fladrafinil powder is supplied and handled as a pharmaceutical intermediate, with emphasis placed on purity, batch consistency, and analytical reproducibility rather than finished-product claims.

 

Key Quality Parameters That Affect Fladrafinil Research and Formulation

 

For overseas procurement teams, evaluating fladrafinil powder quality involves more than simply confirming whether a material meets a minimum purity specification. In research and formulation work, even small variations in purity or impurity composition can influence analytical results, formulation stability, and repeatability across development stages.

 

In professional sourcing practice, the following quality parameters are typically reviewed together rather than in isolation:

 

Quality Parameter	Why It Matters in Research & Formulation
Fladrafinil purity ≥98%	Supports reproducible screening and formulation consistency
High-purity Fladrafinil ≥99%	Reduces background interference in analytical and formulation studies
Impurity profile	Impacts data comparability across batches
Residual solvents	Must comply with ICH Q3C guidelines
Heavy metals	Controlled within pharmacopeial limits
Microbial limits	Relevant for storage stability and handling safety

 

From a formulation and R&D perspective, higher-purity fladrafinil powder (≥99%) is often preferred when the material is used in comparative studies, scale-up trials, or longer development programs. Higher purity helps minimize unknown variables introduced by trace impurities, allowing researchers to focus on functional performance rather than batch-related inconsistencies.

 

At CHEN LANG BIO TECH, we are able to supply high-purity fladrafinil powder with purity levels of 99% and above, produced under controlled manufacturing conditions. This level of purity is particularly valuable for customers engaged in nootropic formulation development, ingredient evaluation, and advanced research applications, where consistency and analytical clarity are critical.

 

Beyond purity, batch-to-batch consistency remains a key consideration. Inconsistent impurity profiles or solvent residues can require additional verification work or reformulation, increasing development time and cost. For this reason, many professional buyers choose to work with a GMP-compliant Fladrafinil manufacturer that maintains in-house quality control and standardized production processes.

 

By combining high-purity fladrafinil raw material, controlled impurity profiles, and complete analytical documentation, suppliers can significantly reduce downstream risk for formulation teams and research organizations.

 

Documentation Required When Sourcing Fladrafinil Powder

 

Complete and transparent documentation is a non-negotiable requirement when sourcing fladrafinil powder for research use. A professional supplier should be able to provide:

 

♦Fladrafinil COA with batch-specific data;

 

♦Fladrafinil MSDS for handling and transport;

 

♦Third-party HPLC analysis;

 

♦Clear batch traceability;

 

♦Storage and stability guidelines.

 

For procurement teams evaluating long-term sourcing options, working directly with a verified manufacturer is the most reliable approach when assessing fladrafinil for sale for research and formulation purposes.

 

Storage, Handling, and Stability of Bulk Fladrafinil Powder

 

Proper handling and storage conditions are essential to maintain the stability of bulk fladrafinil powder throughout international logistics and warehousing.

 

Best practices include:

 

•Storage in cool, dry environments;

 

•Sealed, moisture-resistant packaging;

 

•Protection from direct light;

 

•Controlled conditions during long-term storage.

 

Under appropriate conditions, fladrafinil powder typically maintains stability for up to 24 months, supporting bulk purchasing and phased usage.

 

FAQ

What is the MOQ for fladrafinil powder?

 

Most manufacturers support MOQs starting from 1 kg, depending on project requirements.

Is third-party testing available?

 

Yes. COA, MSDS, and third-party HPLC reports are typically provided upon request.

Can samples be supplied before bulk purchase?

 

Laboratory samples are commonly available for evaluation.

How is Fladrafinil shipped internationally?

 

Standard shipping methods include DHL, FedEx, UPS, or air freight with compliant export documentation.

 

Where to Buy Fladrafinil Powder?

 

Fladrafinil powder is typically sourced based on production background, quality control systems, and the ability to maintain consistent output over time. In applications involving research continuity or formulation development, supply stability and batch consistency are closely linked to manufacturing conditions rather than distribution channels.

 

At CHEN LANG BIO TECH, fladrafinil is produced and supplied directly from our manufacturing facilities. This factory-direct structure allows tighter control over synthesis parameters, impurity profiles, and batch reproducibility, while supporting high-purity Fladrafinil powder with purity levels of 99% and above. Such control is particularly relevant in formulation and research settings where analytical clarity and repeatability are required.

 

Production planning and standardized quality systems enable stable and continuous supply for both small-quantity requirements and larger-volume orders. This helps avoid variability that may arise when sourcing through fragmented or intermediary-based supply chains. Combined with in-house manufacturing, this structure also allows competitive pricing without sacrificing quality or documentation standards.

 

Fladrafinil powder produced under controlled conditions, supported by complete analytical documentation, can meet the requirements of both domestic and international markets across research, formulation, and ingredient supply applications.

 

Factory-direct production with standardized quality control is one of the reasons fladrafinil is increasingly sourced through manufacturers offering fladrafinil for sale with consistent specifications and documentation.

 

For technical details, specifications, or documentation such as COA, MSDS, and third-party analytical reports, further information can be provided upon request.

 

CHEN LANG BIO TECH

 

📧 Email: admin@chenlangbio.com

 

📱 WhatsApp: +86-17782478823

 

References

1, Minzenberg, M. J., & Carter, C. S. Modafinil: A review of neurochemical actions and effects on cognition. Neuropsychopharmacology.

2, Ballon, J. S., & Feifel, D. A systematic review of modafinil. Journal of Clinical Psychiatry.

3, ICH Q3C – Impurities: Guideline for Residual Solvents.

4, ICH Q7 – Good Manufacturing Practice Guide for Active Pharmaceutical Ingredients.

5, PubChem Database: Fladrafinil (CAS 90212-80-9).